Research "Sensors based on ionic associates for the determination of biologically active compounds"

Work number - M 94 AWARDED

Authors: Antal I.P., Savchuk T.I.

Submitted by Lesya Ukrainka East European National University

The series of scientific papers consists of 38 scientific papers, 10 Ukraine patents, 40 conference abstracts published over 6 years in the period from 2006 to 2012.

The research solved a major scientific and technical problem caused by the need to find ways to improve the sensitivity and selectivity of the determination of some biologically active substances that can be implemented by spectrophotometry and potentiometry methods using ion associates of basic dyes.

A number of fundamental results were obtained on the determination of non-steroidal anti-inflammatory drugs (NSAID) and various forms of iodine, organic peroxocompounds, ascorbic acid, sodium sulphite, sodium metamizole and pentachlorophenol.

The series of scientific papers has priority results that are competitive with state-of-the-art global analogs, as evidenced by obtained Ukraine patents.

New approaches were suggested on the possibility of using ion associate of NSAIDs and triiodide, iodine-bromide and pentachlorophenol to create potentiometric sensors with basic dyes in spectrophotometry and ionometry.

The authors set new non-conventional tasks, including invented new analytical forms for the photometric determination of non-steroidal anti-inflammatory drugs and potentiometric determination of various forms of iodine, organic peroxocompounds, ascorbic acid, sodium sulphite, sodium metamizol and pentachlorophenol. New sensitive methods have good metrological characteristics and are easy to use.

The results of the research cycle are important for the analysis of natural and biological objects, foodstuffs, pharmaceuticals. Techniques suitable for use in factory and clinical laboratories, laboratories of the quality control of pharmaceuticals and food products were developed.

The research results were reported in 88 publications, including 38 articles in refereed journals (19 of them are in the Scopus database), 10 patents, 40 abstracts in conference collections. Total citation index is over 5 by the Scopus database. The works of authors were cited in more than 45 (Scopus database) scientific and applied journals.