The construction of aryl-substituted heterocyclic compounds with biological activity and for the application in optoelectronics

Work number - M 51 AWARDED

Author:LytvynR. Z.

          Presented by Ivan Franko National University of Lviv for the Presidential Award for Young Scientists in 2018.

А seriesofthe publicationsconsist of46scientific papers, published during 2003–2016 period.

The purpose of this work is to find new chemo-, regio-, and stereoselective reactions, multicomponent and one-pot syntheses of complex structured compounds with useful properties, in particular, withantitumor, antimicrobial, antifungal bioactivity; the development of new compounds applicable in optoelectronics. The cycle of publications is aimed at studying the cyclization reactions of arylation products of heteroaromatic compounds using strategies based on the use and development of new synthetic methods. As a result, for the first time the arylation of derivatives of pyrrole, sydnone, benzofuroxane, some derivatives of furan, thiophene, coumarin, pyron, pyridone and others under the Meerwein reaction was investigated. The use of diazonium salts avoids the complexity, the need for expensive catalysts and specific conditions. Advantages of arenediazonium salts –high reactivity, the ability to use in various synthetic schemes, low cost and wide variability of the original aromatic amines. The obtained compounds are used in the design of various heterocycles. The practical significance of the cycle of works is determined not only by the development of preparative methods for the synthesis of new derivatives of five-, six-membered heterocycles and mesoionic compounds, but also by the possible application of these methods for obtaining combinatorial libraries and the creation of semiconducting materials. Studies of biological activity (in particular, antimicrobial, antibacterial, antitumor) of synthesized compounds have shown prospects for their further study as hit-leaders. Synthesized materials are characterized by: balanced ampipolar p-, n-semiconductivity, the effect of thermoactivated delayed fluorescence, high fluorescence quantum yields. Some of these materials are used to create organic light emitting diodes (OLEDs).

The results of this workare describedin 46articles (18–journals with impact-factor)and83 abstracts;18patents were received. The works of author were cited in 39scientific journals, totalcitation index 52(Scopus), 65 (Google Scholar),h-index = 5.

Total number of author's publications:177 (55 articles, 97abstracts, 25 patents)

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