Work number - M 64 FILED
Presented by the Institute of Physiology. O.O Bogomolets NAS of Ukraine
to the President of Ukraine award for young scientists
A series of scientific work consists of 56scientific papers published during 7years. The purpose of this series of work was to study the role of mitochondrial dysfunction, oxidative stress and nitrosative stress, functional disorders of the heart and vessels in hypertension and aging and the use of new ways of cardioprotection to prevent these violations. Fundamental results is regarding the contribution of mitochondrial dysfunction, oxidative stress and nitrosative in the development of hypertension and aging. The basis for the correction of cardiac and vascular function in conditions of oxidative stress are restoring the coupling cNOS and increasing de novo synthesis of nitric oxide. A series of scientific papers comprises priority results that combine physiological and biochemical mechanisms of the functioning of the cardiovascular system during aging, hypertension, physical exertion, etc..
New ways of correction of cardiac function are use a physiological ( moderate physical activity) and pharmacological (with using hydrogen sulphide donor and EMAP II). The results of series have a great importance for practical medicine, dedicated to the prevention and treatment of hypertension and diseases of the cardiovascular system in the elderly, accompanied myocardial dysfunction.
The results of research on the topic of work set out in Articles 28(including 14inforeign journals), 24abstracts. Works cited authors in over 30scientific journals, the general index of citing papers is 30(according to the database Scopus), h-index = 4. State patents have received -3.Posted 1 patent.
Total number of authors publications: 99publications