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Controlled synthesis of bionanocomposites, their structure and morphology

Work number - M 22 AWARDED

Presented by the Institute of Applied Physics of NAS of Ukraine.

Authors:Kuznetsov V.M., Trofimenko Y.V.


The aim of the current work was to perform a comprehensive study of the influence of physico-chemical factors (such as synthesis conditions, annealing temperature, the addition of a polymeric component, the presence of carbonate substitutions in the structure of apatite, the influence of the magnetic field of various configurations with and without magnesium ions in the initial solution) on the crystal structure and morphology of materials based on hydroxyapatite and brushite. In order to increase the antibacterial properties of these materials for their further invivo application, different physical methods of decontamination of chitosan based biopolymers were studied, such as autoclaving and radiation treatment, as well as the usage of chitosan materials in conjunction with nanoparticles of metals and other reagents.

The complex experimental researches of the crystal structure and microstructure of calcium-phosphate materials carried out in the current study allowed to receive new scientific results. The relation between crystallinity and microstructure of apatite coatings, obtained by the thermal deposition method on titanium substrates, and the temperature of the substrate was received for the first time. The dependences of the atomic ratio of calcium to phosphorus and the coating mass on the temperature, as well as the increase in the coating mass on the synthesis time, were obtained. On the basis of these dependences the optimal parameters of coatings production are established.

It was found that the increase of chitosan concentration in apatite-based composites leads to the increase of the amount of β‑tricalcium phosphate released after annealing. This fact confirms the presence of chemical interaction between chitosan and calcium phosphate during the crystallization process.

For the first time the novel method of estimation of carbonate quantity and its localization in apatite structure by means of thermoprogrammed extraction of gas sample with chromatographic registration was proposed and tested. The qualitative model of the influence of external magnetic field on the structure of brushite during its crystallization was also proposed for the first time.

The obtained results allow the estimation of the influence of physicochemical factors on the crystal structure and microstructure of biomaterials based on apatite. Changes in the parameters of the crystal structure and microstructure of biomaterials lead to changes in their biomedical and mechanical properties. Systematization of quality and the degree of changes in properties of the crystal structure of calcium phosphates under the influence of physical and chemical factors contributes to the creation of biological products with the specified parameters: degree of solubility, mechanical strength, additional properties and the degree of biomimetic, that can be used in surgery, orthopedy and dentistry for treatment of various bone defects.

Total number of publications on the topic is66. 30 articles, 9 – in the international scientific journals. According to Scopus database, the total amount of citations on these publications is 141. h-index (on this work) – 5. According to Google Scholar database, the total amount of citations is 205, h-index (on this work) – 9.